Searches for exploitable biochemical differences between normal and cancer cells. III. Effects of aminoimidazolecarboxamide on purine metabolism.

Searches for exploitable biochemical differences between normal and cancer cells. II. Nucleic acid purine metabolism in human tumors.

Searches for exploitable biochemical differences between normal and cancer cells. IX. Anabolism and catabolism of purines by hepatomas 5123 and H-35.

The extents of anabolism and catabolism in vitro of purines and purine ribonucleotides by rat tissues, Morris Hepatoma 5123, and Reuber H-35 hepatoma were deter mined. The results are compared with those obtained previously for Novikoff hepato ma. Hepatoma 5123 was more active catabolically than any of the host tissues exam ined, including liver; H-35 tumor was about one-half as active cataboli...

Searches for exploitable biochemical differences between normal and cancer cells. X. Catabolism of purines by regressing tumors.

The in vitro anabolism and catabolism of radioactive purities by minces and of radio active purines and purine ribonucleotides by sonicates of growing and regressing tu mors were investigated with the aid of paper chromatography, radioautography, and radioassay. Two systems of growing and regressing tumors were used: (a) cyclophosphamide-sensitive and cyclophosphamide-resistant plasmacytomas gr...

Comparative study of serum lactic dehydrogenase activity in mice with transplanted and induced tumors.

C. C. Little. Guest Editorial: Smoking and Lung Cancer 188 John H. Lawrence and Cornelius A. Tobias. Radioactive Isotopes and Nuclear Radiations in the Treatment of Cancer 185 R. K. Davis, G. T. Stevenson, and K. A. Busch. Tumor Incidence in Normal Sprague-Dawley Fe male Rats 194 Eldon M. Boyd and Elinor M. Crandell. The Concentration of Lipids and Water in Skeletal Muscle of Albino Rats Bearin...

Investigation on metabolism of cisplatin resistant ovarian cancer using a genome scale metabolic model and microarray data

Objective(s): Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. Material and Methods:Metabolism of c...